Synthesis and Unique Function of a Copper(II) Compound Possessing an Imidazole Moiety as an Anchor Group
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چکیده
A new copper(II) complex with a (bdpg-His) ligand was prepared and its structural properties were investigated both in crystalline and in solution states; (bdpg-His) = N,N-bis(2-pyridylmethyl)carnosine methylester. In the solid state, the complex has a dimeric structure, but in solution it partially dissociates into monomeric species, which have an imidazole moiety as an anchor group. This complex can prevent the precipitation of aggregated amyloid beta-peptide induced by zinc(II) ions, and affects the structure of the superoxide dismutase molecule, leading to the loss of the dimeric structure; these effects are probably due to the free imidazole group of the complex in solution.
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تاریخ انتشار 2007